Androgens: endocrine physiology and pharmacology.

Abstract Text

The ability of eukaryotic organisms of the same genotype to vary in developmental pattern or in phenotype according to varying environmental conditions is frequently associated with changes in extrachromosomal circular DNA (eccDNA) sequences. Although variable in size, sequence complexity, and copy number, the best characterized of these eccDNAs contain sequences homologous to chromosomal DNA which indicates that they might arise from genetic rearrangements, such as homologous recombination. The abundance of repetitive sequence families in eccDNAs is consistent with the notion that tandem repeats and dispersed repetitive elements participate in intrachromosomal recombination events. There is also evidence that a fraction of this DNA has characteristics similar to retrotransposons. It has been suggested that eccDNAs could reflect altered patterns of gene expression or an instability of chromosomal sequences during development and aging. This article reviews some of the findings and concepts regarding eccDNAs and sequence plasticity in eukaryotic genomes.

Authors :-,


Keywords :-, ,


Mesh Headings :-, , , ,


Chemical List :-, ,



2016-09-01 22:48:43

Click download button below to get the free Androgens: endocrine physiology and pharmacology. link to pdf of abstract on your facebook profile.

Download Server - Asia Download Server - America Download Server - Europe Download Server - Australia
Citation:- Winters SJ, .Androgens: endocrine physiology and pharmacology. NIDA research monograph 1990-;102()113-30 DOI:



Details of Journal

Journal Title - NIDA research monograph

ISSN - 1046-9516

Volume - 102

Issue - 0

Publish date - 1990-

Language - eng

Country - UNITED STATES


SHARE PLEASE -
Read More Similar Articles

The androgen-induced phenotype.

Bardin CW, Catterall CW, Jänne CW, .The androgen-induced phenotype. NIDA research monograph 1990-;102()131-41 DOI:.......

Read More

Cicero TJ, O'Connor TJ, .Abuse liability of anabolic steroids and their possible role in the abuse of alcohol, morphine, and other substances. NIDA research monograph 1990-;102()1-28 DOI:.......


Anabolic steroid abuse.

Gaubatz JW, .Anabolic steroid abuse. NIDA research monograph 1990-;102()1-241 DOI:.......

Read More

Extrachromosomal circular DNAs and genomic sequence plasticity in eukaryotic cells.

Gaubatz JW, .Extrachromosomal circular DNAs and genomic sequence plasticity in eukaryotic cells. Mutation research -;237()271-92 DOI:.......

Read More

Homologous recombination is elevated in some Werner-like syndromes but not during normal in vitro or in vivo senescence of mammalian cells.

Cheng RZ, Murano RZ, Kurz RZ, Shmookler Reis RZ, .Homologous recombination is elevated in some Werner-like syndromes but not during normal in vitro or in vivo senescence of mammalian cells. Mutation r.......

Read More

Reduced DNA-repair capacity in cells originating from a progeria patient.

Wang SM, Nishigori SM, Zhang SM, Takebe SM, .Reduced DNA-repair capacity in cells originating from a progeria patient. Mutation research -;237()253-7 DOI:.......

Read More

Age-related increase of mitomycin C-induced micronuclei in lymphocytes from Down's syndrome subjects.

Scarfí MR, Cossarizza MR, Monti MR, Bersani MR, Zannotti MR, Lioi MR, .Age-related increase of mitomycin C-induced micronuclei in lymphocytes from Down's syndrome subjects. Mutation research -;237()2.......

Read More

Comparison of age-associated changes of c-myc gene methylation in liver between man and mouse.

Ono T, Yamamoto T, Kurishita T, Yamamoto T, Yamamoto T, Ujeno T, .Comparison of age-associated changes of c-myc gene methylation in liver between man and mouse. Mutation research -;237()239-46 DOI:.......

Read More

Steady-state levels of 7-methylguanine increase in nuclear DNA of postmitotic mouse tissues during aging.

Tan BH, Bencsath BH, Gaubatz BH, .Steady-state levels of 7-methylguanine increase in nuclear DNA of postmitotic mouse tissues during aging. Mutation research -;237()229-38 DOI:.......

Read More

//google analytics script here