Anti-inflammatory action of glucagon in rats.

Abstract Text

1 Subcutaneous administration of glucagon (1 and 0.5 mg/kg) 30 min before the injection of carrageenin or dextran into the rat's paw reduced oedema and the local exudation of Evans blue previously given intravenously. 2 The effect persisted after removal of the adrenal medulla but not after adrenalectomy. 3 When glucagon (1 mg/kg, s.c.) was given daily after a local reaction to Freund's adjuvant injected into the paw had developed, a decrease in the reaction was observed up to 12 days. Blood sugar levels remained within the normal range. 4 Glucagon may exert an anti-inflammatory effect through the release of adrenal corticosteroids and thus help modulate inflammatory reactions.

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2016-09-01 01:28:34

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Citation:- Garcia Leme J, Morato J, Souza J, .Anti-inflammatory action of glucagon in rats. British journal of pharmacology 1975-Sep;55()65-8 DOI:



Details of Journal

Journal Title - British journal of pharmacology

ISSN - 0007-1188

Volume - 55

Issue - 1

Publish date - 1975-Sep

Language - eng

Country - ENGLAND


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