Astaxanthin stimulates cell-mediated and humoral immune responses in cats.

Abstract Text

Astaxanthin is a potent antioxidant carotenoid and may play a role in modulating immune response in cats. Blood was taken from female domestic shorthair cats (8-9 mo old; 3.2 ± 0.04 kg body weight) fed 0, 1, 5 or 10mg astaxanthin daily for 12 wk to assess peripheral blood mononuclear cell (PBMC) proliferation response, leukocyte subpopulations, natural killer (NK) cell cytotoxic activity, and plasma IgG and IgM concentration. Cutaneous delayed-type hypersensitivity (DTH) response against concanavalin A and an attenuated polyvalent vaccine was assessed on wk 8 (prior to vaccination) and 12 (post-vaccination). There was a dose-related increase in plasma astaxanthin concentrations, with maximum concentrations observed on wk 12. Dietary astaxanthin enhanced DTH response to both the specific (vaccine) and nonspecific (concanavalin A) antigens. In addition, cats fed astaxanthin had heightened PBMC proliferation and NK cell cytotoxic activity. The population of CD3(+) total T and CD4(+) T helper cells were also higher in astaxanthin-fed cats; however, no treatment difference was found with the CD8(+) T cytotoxic and MHC II(+) activated lymphocyte cell populations. Dietary astaxanthin increased concentrations of plasma IgG and IgM. Therefore, dietary astaxanthin heightened cell-mediated and humoral immune responses in cats.

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2016-09-08 02:08:27

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Citation:- Park JS, Mathison JS, Hayek JS, Massimino JS, Reinhart JS, Chew JS, .Astaxanthin stimulates cell-mediated and humoral immune responses in cats. Veterinary immunology and immunopathology 2011-Dec;144()455-61 DOI:10.1016/j.vetimm.2011.08.019

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Details of Journal

Journal Title - Veterinary immunology and immunopathology

ISSN - 1873-2534

Volume - 144

Issue - 3

Publish date - 2011-Dec

Language - eng

Country - Netherlands


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