Asymptomatic visceral leishmaniasis in a patient with acquired immunodeficiency syndrome].

Abstract Text

We report an adult patient with systemic Langerhans' cell histiocytosis (LHX), who was refractory to multiple chemotherapy courses and in whom a partial clinical and biological 3-month remission was achieved with alpha-2-interferon. The patient's response was associated with an increase in the rate of natural killer cells and to a return to normal of the H/S T-lymphocyte ratio. Immunological abnormalities have been reported in this condition, and it is now accepted that the most important one is a decrease in suppressor lymphocytes. However, it is not known whether these abnormalities are endogenous or exogenous. The experience with modifiers of the biological response for the treatment of LHX is scanty, but the probable immunological pathogenesis of the condition justifies a therapeutic trial of those agents in patients not responding to conventional therapy.

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Citation:- Sirera G, Millá G, Condom G, Clotet G, .Asymptomatic visceral leishmaniasis in a patient with acquired immunodeficiency syndrome]. Medicina clínica 1990-Feb;94()196 DOI:



Details of Journal

Journal Title - Medicina clínica

ISSN - 0025-7753

Volume - 94

Issue - 5

Publish date - 1990-Feb

Language - spa

Country - SPAIN


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