Beta-glucuronidase in physiology and disease.

Abstract Text

beta-glucoronidase (EC 3.2.1.31) is a lysosomal enzyme catylysing the decomposition of beta-D-glucoronides--compounds arising as a result of the combination of beta-D-glucoronic acid and a number of compounds both exo- and endogenous, containing hydroxylic, carboxylic, amine, imine or thiol groups. The most common test evaluating the activity of the enzyme is that using phenolphtalein glucoronide as a biosynthetic substrate. The freed aglycons are colorimetrically assayed. The activity of beta-glucoronidase increases in many pathological conditions: liver infammations, cirrhosis of the liver, inflammations of other organs, cholestatic jaundice, tuberculosis, sarcoidosis and also in neoplasms. Many authors point to beta-glucoronidase as a sensitive indicator signalling cell damage.

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2016-09-03 18:21:42

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Citation:- Basińska A, Floriańczyk A, .Beta-glucuronidase in physiology and disease. Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina 2003-;58()386-9 DOI:



Details of Journal

Journal Title - Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina

ISSN - 0066-2240

Volume - 58

Issue - 2

Publish date - 2003-

Language - eng

Country - Poland


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